blood brain barrier
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Function
- opposes passage of most ions & large molecular weight compounds from the blood into the cerebrospinal fluid & brain tissue
Structure
- continuous layer of endothelial cells connected by tightcjunctions
- similar capillaries are found in the retina, iris, inner ear & endoneurium of peripheral nerves
- in circumventricular organs, the blood brain barrier is absent; the endothelium is fenestrated
- the blood-CSF barrier is provided by tight junctions between ependymal cells
Pathology
- breakdown of the blood brain barrier occurs in many neurodegenerative disorders[3]
Comparative biology
- p16INK4a expressing (dubbed senescent) endothelial cells associated with compromised blood brain barrier in mice[2]
More general terms
Additional terms
Component of
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ 2.0 2.1 Yamazaki Y, Baker DJ, Tachibana M et al Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke. 2016 Feb 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26883501
- ↑ 3.0 3.1 Sweeney MD, Sagare AP, Zlokovic BV Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews Neurology. Jan 29, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29377008 https://www.nature.com/articles/nrneurol.2017.188