lipoprotein
Jump to navigation
Jump to search
Introduction
An operational classification of lipoproteins is based upon their sizes, floating densities in an ultracentrifuge & electrophoretic mobilities.
Function
Structure
- the major lipoprotein species differ in size
- the less dense, less water-soluble lipoproteins are larger than the more dense lipoproteins
- thus the size of lipoproteins varies from chylomicrons > VLDL > LDL > HDL Size of the major lipoprotein species.
| Lipoprotein | diameter (nm) | density (g/mL) |
|---|---|---|
| Chylomicrons | 80-500 | < 0.950 |
| VLDL | 30-100 | 0.950-1.006 |
| IDL | 22-24 | 1.006-1.019 |
| LDL | 20-23 | 1.019-1.063 |
| HDL | 4-10 | 1.063-1.210 |
Constituents
- the major lipoprotein species differ in composition.
- the less dense, less water-soluble, lipoproteins contain greater amounts of triglycerides than the more dense lipoproteins
- thus the triglyceride content of lipoproteins varies from chylomicrons > VLDL > LDL > HDL
- conversely, the more dense, more water soluble lipoproteins contain greater amounts of apolipoprotein
- thus the protein content of lipoproteins varies from HDL > LDL > VLDL > chylomicrons
- cholesterol content of lipoproteins is greatest in LDL & lowest in chylomicrons Composition of major lipoprotein species.
| Lipoprotein | %triglyceride | %cholesterol | %protein |
|---|---|---|---|
| Chylomicrons | 85 | 5 | 2 |
| VLDL | 60 | 15 | 10 |
| LDL | 10 | 45 | 25 |
| HDL | 5 | 15 | 50 |
More general terms
More specific terms
- apolipoprotein
- bassoon; zinc finger protein 231 (BSN, KIAA0434, ZNF231)
- Ca+2/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cam-PDE 1B; 63 kD Cam-PDE (PDE1B, PDE1B1, PDES1B)
- CD7; T-cell antigen CD7; GP40; T-cell leukemia antigen; TP41
- chylomicron
- coupling factor 0 (F0, CF0)
- DnaJ homolog subfamily C member 5; cysteine string protein; CSP (DNAJC5, CSP)
- high density lipoprotein (HDL, alpha-lipoprotein)
- intermediate density lipoprotein (IDL) or VLDL remnant
- lipid transfer protein
- lipoprotein <a>; Lp<a>
- lipoprotein-X (LpX)
- lpx lipoprotein
- myelin & lymphocyte protein; T-lymphocyte maturation-associated protein (MAL)
- paralemmin (PALM KIAA0270)
- phosphodiesterase 2 (PDE2) or cGMP stimulated phosphodiesterase
- prostate stem cell antigen (PSCA)
- ras GTPase inhibitor
- very low density lipoprotein (VLDL)
Additional terms
Components
References
- ↑ Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1024