CD7; T-cell antigen CD7; GP40; T-cell leukemia antigen; TP41

Function

• unknown
• interacts with SECTM1

Structure

contains 1 Ig-like (immunoglobulin-like) domain

Compartment

membrane

Expression

• present on most T-cells
  • mature peripheral T cells ~85%
  • most post-thymic T cells
• most NK cells
• some myeloid cells

Pathology

• expressed in:
  • T-cell ALL
  • AML (especially AML-M4, AML-M5)
  • chronic myelogenous leukemia
• adult T cell leukemia/lymphoma, Sezary syndrome, B-cell ALL show negative staining with antibody

More general terms

• CD antigen
• glycoprotein
• lipoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:924
• OMIM: https://mirror.omim.org/entry/186820
• UniProt: http://www.uniprot.org/uniprot/P09564.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=924