AML-M4; acute myelomonocytic leukemia

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Pathology

myelocytic & monocytic differentiation evident
myeloid elements resemble M2; peripheral monocytosis.

Genetics

chromosomal translocation t(5;17)(q33;p11.2) involving SPECC1 with PDGFRB may be a cause of juvenile myelomonocytic leukemia
chromosomal translocation t(5;11)(q31;q23) involving ARHGAP26 with MLL has been found in a case of juvenile myelomonocytic leukemia

More general terms

acute myeloid leukemia (AML)

More specific terms

Additional terms

core-binding factor [CBF]-beta; polyomavirus enhancer binding protein 2 beta; PEBP2-beta; SL3/AKV core-binding factor beta; SL3-3 enhancer factor 1 beta (CBFB)

References

↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 726
↑ Liu et al, Fusion between transcription factor CBF beta/PEB2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8351518
↑ Mihova D Leukemia - Acute AML not otherwise categorized Acute myelomonocytic leukemia (FAB AML M4) Pathology Outlines http://www.pathologyoutlines.com/topic/leukemiaM4.html

Patient information

acute myelomonocytic leukemia patient information

Database

OMIM: https://mirror.omim.org/entry/607785

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