sperm antigen with calponin homology & coiled-coil domains 1 (nuclear structure protein 5, NSP5, sperm antigen HCMOGT-1, SPECC1, NSP5)

Structure

• belongs to the cytospin-A family

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• highly expressed in testis
• arely detectable in other tissues

Pathology

• highly expressed in some cancer cell lines
• chromosomal translocation t(5;17)(q33;p11.2) involving SPECC1 with PDGFRB may be a cause of juvenile myelomonocytic leukemia

More general terms

• testis-specific protein
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5M775.html