PDGF receptor-beta (PDGFRB)
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Function
- binds PDGF beta & PDGF alpha-beta
- soluble PDGFR-beta is a CSF biomarker of blood-brain-barrier associated capillary mural cell pericyte function[4]
Expression
- pericytes, arterial smooth muscle cells
Pathology
- diminished expression in Alzheimer' disease subtype 5
More general terms
References
- ↑ Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
- ↑ Koch CA, Anderson D, Moran MF, Ellis C, Pawson T. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science. 1991 May 3;252(5006):668-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1708916
- ↑ Pawson T. Protein modules and signalling networks. Nature. 1995 Feb 16;373(6515):573-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
- ↑ 4.0 4.1 Nation DA, Sweeney MD, Montagne A et al Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine 2019. Jan 14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30643288 https://www.nature.com/articles/s41591-018-0297-y