platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; proto-oncogene c-sis; Becaplermin (PDGFB, PDGF2, SIS)
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Function
- growth factor
- role in regulation of embryonic development, cell proliferation, cell migration, survival & chemotaxis
- potent mitogen for cells of mesenchymal origin
- required for
- normal proliferation & recruitment of pericytes & vascular smooth muscle cells in the central nervous system, skin, lung, heart & placenta
- normal blood vessel development
- normal development of renal glomeruli
- role in wound healing
- signaling is modulated by the formation of heterodimers with PDGFA
- homodimer; antiparallel disulfide-linked dimer
- heterodimer with PDGFA; antiparallel disulfide-linked dimer
- PDGFB homodimer interacts with PDGFRA & PDGFRB homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- the heterodimer composed of PDGFA & PDGFB interacts with PDGFRB homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- interacts with XLKD1 (putative)
Structure
- belongs to the PDGF/VEGF growth factor family
Compartment
Expression
- expressed at high levels in the heart, brain (substantia nigra), placenta & fetal kidney
- expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney & lung
Pathology
- chromosomal translocation t(17;22)(q22;q13) involving PDGFB with COL1A1 is found in dermatofibrosarcoma protuberans
Pharmacology
- available under the name Regranex (Ortho-McNeil)
- used to promote healing in neuropathic diabetic foot ulcers
More general terms
More specific terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P01127.html
- ↑ R&D systems' cytokine source book: PDGF http://www.rndsystems.com/molecule_detail.aspx?m=1967
- ↑ Regranex; Note: Clinical information on Regranex http://www.regranex.com/
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/PDGFBID155.html
- ↑ Matsui T et al, Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes Science 243:800 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2536956
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908