lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; cell surface retention sequence-binding protein 1; CRSBP-1 hyaluronic acid receptor; extracellular link domain-containing protein 1 (XLKD1, LYVE1, CRSBP1, HAR, UNQ230/PRO263)

Function

• ligand-specific transporter trafficking between intracellular organelles (trans Golgi) & the plasma membrane
• role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding
• hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake & degradation in lymph nodes
• interacts with PDGFB & IGFBP3
• forms a transient ternary complex with PDGFB & PDGFRB in trans Golgi

Structure

• homodimer, disulfide-linked
• O-glycosylated
• contains 1 Link domain

Compartment

• plasma membrane, trans-Golgi, endosomes
• undergoes ligand-dependent internalization & recycling at cell surface

Expression

• expressed in endothelial cells lining lymphatic vessels

More general terms

• carrier protein (transporter)
• cell surface receptor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/605702
• UniProt: http://www.uniprot.org/uniprot/Q9Y5Y7.html