disulfide bridge

Introduction

Cross links formed from oxidized cysteine residues. Intracellular proteins usually lack disulfides; extracellular proteins often contain several.

Oxidizing equivalents for disulfide bond formation are provided by a flavoprotein monooxygenase within the endoplasmic reticulum.

More general terms

• peptide motif
• exoplasmic motif

More specific terms

• redox-modulated thiol disulfide

Additional terms

• cystine
• flavoprotein mixed function oxidase; flavoprotein monooxygenase; dimethylaniline oxidase; dimethylaniline monooxygenase [N-oxide forming] (FMO)