dermatofibrosarcoma protuberans
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Introduction
Tumor of intermediate malignancy.
Pathology
Genetics
- reciprocal translocations t(17;22)(q22;q13) fuse PDGF-B (c-sis proto-oncogene) with COL1A1 & delete exon 1 of PDGF-B
- releasing growth factor from normal regulation.
Laboratory
More general terms
References
- ↑ Simon et al. Nature Genet 15:95-8, 1997
- ↑ Szollozi Z et al, Transformed dermatofibrosarcoma protuberans: Real time polymerase charin reaction detection of COL1A1-PDGFB fusion transcripts in sarcomatous areas. J Clin Pathol 2007, 60:190 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16731589
Maire G et al, A clinical, histological and molecular study of 9 cases of congenital dermatofibrosarcoma protuberans. Arch Dermatol 2007, 143:203 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17310000