platelet-derived growth factor subunit A; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide (PDGFA, PDGF1)
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Function
- growth factor
- role in regulation of embryonic development, cell proliferation, cell migration, cell survival & chemotaxis
- potent mitogen for cells of mesenchymal origin
- required for
- normal lung alveolar septum formation during embryogenesis
- normal development of the GI tract
- normal development of Leydig cells
- spermatogenesis
- normal oligodendrocyte development
- normal myelination in the spinal cord & cerebellum
- role in wound healing
- may provide neuronal signal for glial differentiation in CNS
- signaling is modulated by the formation of heterodimers with PDGFB (putative)
- homodimer; antiparallel disulfide-linked dimer
- heterodimer with PDGFB; antiparallel disulfide-linked dimer
- the PDGFA homodimer interacts with PDGFRA homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- the heterodimer composed of PDGFA & PDGFB interacts with PDGFRA homodimers, & with heterodimers formed by PDGFRA & PDGFRB
- interacts with CSPG4
Structure
- the long form contains a basic insert which acts as a cell retention signal
- belongs to the PDGF/VEGF growth factor family
Compartment
Alternative splicing
named isoforms=2; long, short
Expression
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P04085.html
- ↑ R&D systems' cytokine mini-reviews: PDGF http://www.rndsystems.com/molecule_detail.aspx?m=1967
- ↑ Matsui T et al, Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes Science 243:800 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2536956
- ↑ Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1589908