chondroitin sulfate proteoglycan 4 (chondroitin sulfate proteoglycan NG2, melanoma chondroitin sulfate proteoglycan, melanoma-associated chondroitin sulfate proteoglycan, CSPG4, MCSP, MEL-CSPG, MSK16)
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Function
- proteoglycan
- cell proliferation & migration
- stimulates endothelial cells motility during microvascular morphogenesis
- inhibits neurite outgrowth & growth cone collapse during axon regeneration
- cell surface receptor for collagen-6 alpha-2
- facilitates migration on collagen-6 alpha-2
- binds extracellular matrix proteases, modulates activity
- regulates MPP16-dependent degradation
- enhances plasminogen activation (putative)
- inhibits angiostatin (putative)
- signal transduction via binding scaffold proteins (putative)
- retraction fiber formation & cell polarization via Rho GTPase activation.
- stimulates alpha-4 integrin & beta-1 integrin mediated adhesion
- recruits activates a signaling cascade through CDC42, ACK1 & BCAR1 (putative)
- activate FAK & ERK1/ERK2 signaling cascades (putative)
- interacts with the first PDZ domain of MPDZ
- interacts with PRKCA
- binds TNC, laminin-1, COL5A1, COL6A2
- interacts with PLG & angiostatin
- binds FGF2 & PDGFA
- interacts with GRIP1, GRIP2 & GRIA2
- interacts with LGALS3 & the integrin (ITGB1/ITGA3)
- interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan
- interacts with BCAR1, CDC42 & ACK1
- interacts with MMP16
- N-glycosylated O-glycosylated
- contains glycosaminoglycan chondroitin sulfate
- phosphorylation by PRKCA regulates its subcellular location & function in cell motility
- contains 15 CSPG (NG2) repeats
- contains 2 laminin G-like domains
Compartment
- cell membrane
- localized at the apical plasma membrane
- relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA
- localizes to the retraction fibers
- localizes to the plasma membrane of oligodendrocytes
Pathology
- detected in malignant melanoma cells