galectin-3; galactose-specific lectin 3; mac-2 antigen; IgE-binding protein; 35 kD lectin; carbohydrate-binding protein 35; CBP 35; laminin-binding protein; lectin L-29; L-31; galactoside-binding protein; GALBP (LGALS3 MAC2)

Function

• galactose-specific lectin which binds IgE
• in conjunction with alpha-3, beta-1 integrin & CSPG4, may facilitate endothelial cell migration
• together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (putative)
• forms a complex with ITGA3, ITGB1 & CSPG4
• interacts with LGALS3BP, LYPD3, UACA & CYHR1
• probably forms homodimers or heterodimers

Structure

contains 1 galectin domain

Compartment

• nucleus
• cytoplasmic in adenomas & carcinomas
• may be secreted by a non-classical secretory pathway & associate with cell surface

Expression

• expressed in colonic epithelium & activated macrophages

More general terms

• galaptin
• phosphoprotein

Additional terms

• galectin-3-binding protein (lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Mac-2 BP, MAC2BP, tumor-associated antigen 90K, LGALS3BP, M2BP)

Database

• UniProt: http://www.uniprot.org/uniprot/P17931.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3958
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3958
• OMIM: https://mirror.omim.org/entry/153619