galectin-3-binding protein (lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, Mac-2 BP, MAC2BP, tumor-associated antigen 90K, LGALS3BP, M2BP)

Function

• promotes integrin-mediated cell adhesion
• may stimulate host defense against viruses & tumor cells
• binds LGALS1, LGALS3, ITGB1, COL4A1, COL5A1, COL6A1, FN1, NID

Structure

• homodimers & homomultimers
• multimers form ring-like structures with a diameter of 30-40 nm

Compartment

secreted

Expression

• ubiquitous
• detected in body fluids, i.e. semen, milk, serum, tears, saliva & urine

More general terms

• secreted protein
• glycoprotein

Additional terms

• galectin-3; galactose-specific lectin 3; mac-2 antigen; IgE-binding protein; 35 kD lectin; carbohydrate-binding protein 35; CBP 35; laminin-binding protein; lectin L-29; L-31; galactoside-binding protein; GALBP (LGALS3 MAC2)

Database

• OMIM: https://mirror.omim.org/entry/600626
• UniProt: http://www.uniprot.org/uniprot/Q08380.html