galectin-1; lectin galactoside-binding soluble 1; beta-galactoside-binding lectin L-14-I; lactose-binding lectin 1; S-lac lectin 1; galaptin; 14 kD lectin; HPL; HBL; MAPK-activating protein PM12 (LGALS1)

Function

• may regulate apoptosis, cell proliferation & cell differentiation
• binds beta-galactoside & a wide array of complex carbohydrates
• inhibits CD45 protein phosphatase activity & thus dephosphorylation of Lyn kinase
• binds LGALS3BP
• interacts with CD2, CD3, CD4, CD7, CD43 & CD45

Structure

• homodimer
• contains 1 galectin domain

Compartment

• secreted, extracellular space, extracellular matrix

Expression

• expressed in cardiac muscle, smooth muscle, skeletal muscle, neurons, thymus, kidney, placenta & hematopoietic cells

More general terms

• galaptin

Database

• UniProt: http://www.uniprot.org/uniprot/P09382.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3956
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3956
• OMIM: https://mirror.omim.org/entry/150570