Lyn proto-oncogene protein (tyrosine-protein kinase Lyn, LYN)
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Function
- interacts with phosphorylated LIME1 upon BCR activation
- interacts with Epstein-Barr virus LMP2A
- interacts with TGFB1I1
- signal transduction through CD19 & lyn &/or constitutive activity of Lyn may inhibit apoptosis of B-cells[2].
Structure
- belongs to the Tyr protein kinase family, SRC subfamily
- contains 1 protein kinase domain
- contains 1 SH2 domain
- contains 1 SH3 domain
Alternative splicing
named isoforms=2
Expression
Pathology
- expressed in primary neuroblastoma tumors
- expressed in transformed T-cells, but not in normal T-cells
More general terms
References
- ↑ Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1281458
- ↑ 2.0 2.1 Myers DE, Jun X, Waddick KG, Forsyth C, Chelstrom LM, Gunther RL, Tumer NE, Bolen J, Uckun FM. Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9575-9. Erratum in: Proc Natl Acad Sci U S A 1996 Feb 6;93(3):1357. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7568175
- ↑ UniProt http://www.uniprot.org/uniprot/P07948.html