Lck-interacting transmembrane adapter 1 (Lck-interacting membrane protein, Lck-interacting molecule, LIME1, LIME, LP8067)
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Function
- role in BCR (B-cell antigen receptor)-mediated signaling in B-cells & TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells
- in absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation
- couples activation of these receptors & their associated kinases with distal intracellular events including as Ca+2 mobilization &/or MAPK activation via recruitment of PLCG2, GRB2, GRAP2, & other signaling molecules
- when phosphorylated in response to BCR activation, interacts with LYN, PIK3R1, PLCG2, & GRB2 (putative)
- when phosphorylated in response to TCR stimulation &/or CD4 co-stimulation, interacts with LCK, CSK, FYN, PTPN11/SHP2, GRB2, PIK3R1 & GRAP2
- palmitoylation of Cys-28 & Cys-31 is required for lipid raft targeting
- phosphorylated on tyrosines upon TCR activation &/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to recruitment of SH2-containing proteins
Compartment
- cell membrane
- present in lipid rafts
- recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
Alternative splicing
named isoforms=2
Expression
- expressed in peripheral blood lymphocytes, lymphoid tissues, & liver.
- present in T-cells & plasma cells, & in various hematopoietic cell lines (at protein level)