mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase
Jump to navigation
Jump to search
Function
- features of MAP kinases include
- activation by direct phosphorylation without a regulatory subunit
- dual phosphorylation by MAP kinase kinase (MEK) - usually two (one Tyr & one Thr) phosphorylation sites in the kinase activation loop[6]
- may act downstream of p34cdc2 & may indirectly inactivate p34cdc2[1]
- MAP kinases are also activated by integrin cross-linking possibly via src[5]
More general terms
More specific terms
- c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK)
- extracellular signal regulated kinase [ERK] family protein
- human EGF receptor family-associated p40hera
- mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; ERK-7; extracellular signal-regulated kinase 8; ERK-8 (MAPK15, ERK7, ERK8)
- p38MAPK subfamily
Additional terms
References
- ↑ 1.0 1.1 Pelech SL, Sanghera JS. Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci. 1992 Jun;17(6):233-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1323888
Pelech SL, Sanghera JS. MAP kinases: charting the regulatory pathways. Science. 1992 Sep 4;257(5075):1355-6. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1382311 - ↑ Rossomando AJ, Payne DM, Weber MJ, Sturgill TW. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc Natl Acad Sci U S A. 1989 Sep;86(18):6940-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2550926
- ↑ Ballou LM, Luther H, Thomas G. MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways. Nature. 1991 Jan 24;349(6307):348-50. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1702881
- ↑ Payne DM, Rossomando AJ, Martino P, Erickson AK, Her JH, Shabanowitz J, Hunt DF, Weber MJ, Sturgill TW. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 1991 Apr;10(4):885-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1849075
- ↑ 5.0 5.1 Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
- ↑ 6.0 6.1 Pearson et al, Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 22:153-83, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11294822