mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; ERK-7; extracellular signal-regulated kinase 8; ERK-8 (MAPK15, ERK7, ERK8)

Function

• activated by Thr & Tyr phosphorylation
• inhibited by dual specificity phosphatases, DUSP1
• interacts with CSK, ABL1, RET
• autophosphorylated on Thr, Tyr
• ubiquitinated by SCF E3 ligase

Structure

• the N-terminal region (1-20) is the minimal region necessary for ubiquitination & proteasomal degradation
• the TXY motif contains the phospho-Thr site & phospho-Tyr site whose phosphorylation activates MAP kinases
• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=3

Expression

• widely expressed
• greatest expression in lung, kidney

More general terms

• MAP kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=225689
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:225689
• UniProt: http://www.uniprot.org/uniprot/Q8TD08.html