Tyrosine phosphorylation site

Introduction

Tyrosine residue phosphorylated by tyrosine kinase.

Phosphotyrosine has an elongated structure & apparently plays a crucial role in molecular recognition & the formation of protein/ protein complexes mediated largely, if not entirely, through SH2 (src homology-2) domains. The specificity tyrosine phosphate for SH2-domains is regulated by residues C-terminal to the phosphorylated tyrosine residue.

More general terms

• phosphorylation site
• tyrosine residue (Tyr, Y)

Additional terms

• src homology 2 [SH2] domain
• tyrosine kinase (protein tyrosine kinase, PTK)