E3 ubiquitin ligase; ubiquitin-ligating enzyme E3; N end-recognizing protein
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Classification
- HECT domain containing
- RING-finger type
- U-box proteins
Function
- catalyzes 3rd step of ubiquitination
- accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, in the form of a thiolester & transfers it to specific substrates, generally promoting their degradation by the proteasome
- determines substrate specificity of ubiquitination
More general terms
More specific terms
- ankyrin repeat & IBR domain-containing protein 1 (ANKIB1, KIAA1386)
- apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1, KIAA0317)
- autocrine motility factor receptor (AMF receptor, gp78, AMFR)
- Baculoviral IAP repeat-containing protein 4; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein; X-linked IAP; IAP-like protein; HILP (XIAP, API3, BIRC4, IAP3)
- BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (KLHL20)
- BRCA1-associated protein (BRAP2, impedes mitogenic signal propagation, IMP, RING finger protein 52, NY-REN-63 antigen, BRAP, RNF52)
- cbl proto-oncogene protein (E3 ubiquitin-protein ligase CBL, signal transduction protein CBL, proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene protein, RING finger protein 55, BL, CBL2, RNF55)
- CCR4-NOT transcription complex subunit 4; CCR4-associated factor 4; E3 ubiquitin-protein ligase CNOT4; transcriptional repressor NOT4Hp (CNOT4, NOT4)
- constitutive photomorphogenic protein 1 (E3 ubiquitin-protein ligase RFWD2, RING finger & WD repeat domain protein 2, RFWD2)
- CUL3/KLHL12 ubiquitin protein E3 ligase complex
- E3 ubiquitin-protein ligase Arkadia (RING finger protein 111, RNF111)
- E3 ubiquitin-protein ligase BRE1A; BRE1-A; hBRE1; RING finger protein 20 (RNF20, BRE1A)
- E3 ubiquitin-protein ligase BRE1B; BRE1-B; 95 kD retinoblastoma-associated protein; RBP95; RING finger protein 40 (RNF40, BRE1B, KIAA0661)
- E3 ubiquitin-protein ligase CBL-B; Casitas B-lineage lymphoma proto-oncogene b; RING finger protein 56; SH3-binding protein CBL-B; signal transduction protein CBL-B (CBLB, RNF56, Nbla00127)
- E3 ubiquitin-protein ligase CCNB1IP1; cyclin-B1-interacting protein 1; human enhancer of invasion 10; E3 ubiquitin-protein ligase HEI10 (CCNB1IP1, C14orf18, HEI10)
- E3 ubiquitin-protein ligase CHFR; checkpoint with forkhead & RING finger domains protein; RING finger protein 196 (CHFR, RNF196)
- E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138 (DZIP3, KIAA0675)
- E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kD; FAAP43 (FANCL, PHF9)
- E3 ubiquitin-protein ligase HACE1 (HECT domain & ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320)
- E3 ubiquitin-protein ligase Hakai (Casitas B-lineage lymphoma transforming sequence-like protein 1, c-Cbl-like protein 1, RING finger protein 188, CBLL1, HAKAI, RNF188)
- E3 ubiquitin-protein ligase HECTD1; E3 ligase for inhibin receptor; EULIR; HECT domain-containing protein 1 (HECTD1, KIAA1131)
- E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2, HECTD2)
- E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3, HECTD3)
- E3 ubiquitin-protein ligase HECW1; C2 & WW domain-containing protein 1; NEDD4-like ubiquitin-protein ligase 1; hNEDL1 (HECW1, KIAA0322, NEDL1)
- E3 ubiquitin-protein ligase HECW2 (HECT, C2 & WW domain-containing protein 2; NEDD4-like ubiquitin-protein ligase 2; HECW2; KIAA1301; NEDL2)
- E3 ubiquitin-protein ligase HERC1 (HECT domain & RCC1-like domain-containing protein 1, p532, p619, HERC1)
- E3 ubiquitin-protein ligase HERC4 (HECT domain & RCC1-like domain-containing protein 4, HERC4, KIAA1593)
- E3 ubiquitin-protein ligase HERC6 (HECT domain & RCC1-like domain-containing protein 6, HERC6)
- E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; ARF-BP1; HECT, UBA & WWE domain-containing protein 1; homologous to E6AP carboxyl terminus homologous protein 9; HectH9; large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; mule; upstrea...
- E3 ubiquitin-protein ligase Itchy homolog; Itch; atrophin-1-interacting protein 4; AIP4; NFE2-associated polypeptide 1; NAPP1 (ITCH)
- E3 ubiquitin-protein ligase KCMF1; K+ channel modulatory factor; PCMF; FGF-induced in gastric cancer; ZZ-type zinc finger-containing protein 1 (KCMF1, FIGC, ZZZ1)
- E3 ubiquitin-protein ligase KIAA1333 (G2E3)
- E3 ubiquitin-protein ligase LINCR (lung-inducible neuralized-related C3CH4 RING domain-containing protein, LINCR)
- E3 ubiquitin-protein ligase LNX; ligand of Numb-protein X 1; Numb-binding protein 1 (LNX1, LNX, UNQ574/PRO1136)
- E3 ubiquitin-protein ligase LRSAM1; EC=6.3.2.-; leucine-rich repeat & sterile alpha motif-containing protein 1; Tsg101-associated ligase; hTAL (LRSAM1, TAL, UNQ6496/PRO21356)
- E3 ubiquitin-protein ligase MARCH1 (membrane-associated RING finger protein 1, membrane-associated RING-CH protein 1, MARCH-1, RING finger protein 171, MARCH1, RNF171)
- E3 ubiquitin-protein ligase MARCH11 (membrane-associated RING finger protein 11, MARCH-XI, MARCH11)
- E3 ubiquitin-protein ligase MARCH5 (membrane-associated RING finger protein 5, membrane-associated RING-CH protein V, MARCH-5, RING finger protein 153, MARCH5, RNF153)
- E3 ubiquitin-protein ligase MARCH6 (membrane-associated RING finger protein 6, membrane-associated RING-CH protein VI, MARCH-VI, RING finger protein 176, protein TEB-4, Doa10 homolog, MARCH6, KIAA0597, RNF176, TEB4)
- E3 ubiquitin-protein ligase MARCH7 (membrane-associated RING finger protein 7, membrane-associated RING-CH protein VII, MARCH-7, RING finger protein 177, axotrophin, MARCH7, AXOT, RNF177)
- E3 ubiquitin-protein ligase MARCH8 (membrane-associated RING finger protein 8. membrane-associated RING-CH protein VIII, MARCH-VIII, RING finger protein 178, cellular modulator of immune recognition, c-MIR, MARCH8, MIR, RNF178)
- E3 ubiquitin-protein ligase MARCH9 (membrane-associated RING finger protein 9, membrane-associated RING-CH protein IX, MARCH-IX, RING finger protein 179, MARCH9, RNF179)
- E3 ubiquitin-protein ligase Mdm2; p53-binding protein Mdm2; oncoprotein Mdm2; double minute 2 protein; Hdm2 (MDM2)
- E3 ubiquitin-protein ligase MGRN1; Mahogunin RING finger protein 1; RING finger protein 156 (MGRN1, KIAA0544, RNF156)
- E3 ubiquitin-protein ligase MID2; midin-2; midline defect 2; midline-2; RING finger protein 60; tripartite motif-containing protein 1 (MID2, FXY2, RNF60, TRIM1)
- E3 ubiquitin-protein ligase MYLIP; inducible degrader of the LDL-receptor; Idol; myosin regulatory light chain interacting protein; MIR (MYLIP, BZF1, IDOL, BM-023, PP5242)
- E3 ubiquitin-protein ligase NEDD4-like; NEDD4.2; Nedd4-2 (NEDD4L, KIAA0439, NEDL3)
- E3 ubiquitin-protein ligase NEDD4; cell proliferation-inducing gene 53 protein; neural cell expressed developmentally down-regulated protein 4; NEDD-4 (NEDD4, KIAA0093, NEDD4-1, PIG53)
- E3 ubiquitin-protein ligase NEURL3; neuralized-like protein 3 (NEURL3, NEURL1B)
- E3 ubiquitin-protein ligase NHLRC1; malin; NHL repeat-containing protein 1 (NHLRC1, EPM2B)
- E3 ubiquitin-protein ligase parkin; EC=6.3.2.-; parkinson juvenile disease protein 2; parkinson disease protein 2 (PARK2 PRKN)
- E3 ubiquitin-protein ligase Praja-1; Praja1; RING finger protein 70 (PJA1, RNF70)
- E3 ubiquitin-protein ligase Praja2 (Praja-2, RING finger protein 131, PJA2, KIAA0438, RNF131)
- E3 ubiquitin-protein ligase RAD18; postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 (RAD18, RNF73)
- E3 ubiquitin-protein ligase rififylin (RING finger & FYVE-like domain-containing protein 1, FYVE-RING finger protein Sakura, Fring, caspases-8 & -10-associated RING finger protein 2, CARP-2, caspase regulator CARP2, RING finger protein 189, RING finger...
- E3 ubiquitin-protein ligase RING1; RING finger protein 1; polycomb complex protein RING1 (RING1, RNF1)
- E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; HIP2-interacting protein 3; protein DinG; RING finger protein 1B; RING1b; RING finger protein 2; RING finger protein BAP-1 (RNF2, BAP1, DING, HIPI3, RING1B)
- E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex protein 1; RING finger protein 123 (RNF123, KPC1, FP1477)
- E3 ubiquitin-protein ligase RNF125; RING finger protein 125; T-cell RING activation protein 1; TRAC-1; RNF125
- E3 ubiquitin-protein ligase RNF128; RING finger protein 128; gene related to anergy in lymphocytes protein (RNF128, GRAIL)
- E3 ubiquitin-protein ligase RNF138 (RING finger protein 138, Nemo-like kinase-associated RING finger protein, NLK-associated RING finger protein, RNF138, NARF, HSD-4)
- E3 ubiquitin-protein ligase RNF144A; RING finger protein 144A; ubiquitin-conjugating enzyme 7-interacting protein 4; UbcM4-interacting protein 4 (RNF144A, KIAA0161, RNF144, UBCE7IP4)
- E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein (RNF144B, IBRDC2, P53RFP)
- E3 ubiquitin-protein ligase RNF149 (RING finger protein 149, DNA polymerase-transactivated protein 2, RNF149, DNAPTP2)
- E3 ubiquitin-protein ligase RNF167 (RING finger protein 167, RING105, RNF167)
- E3 ubiquitin-protein ligase RNF216; RING finger protein 216; ubiquitin-conjugating enzyme 7-interacting protein 1; zinc finger protein inhibiting NF-kappa-B; triad domain-containing protein 3 (RNF216, TRIAD3, UBCE7IP1, ZIN)
- E3 ubiquitin-protein ligase RNF25 (RING finger protein 25, RNF25)
- E3 ubiquitin-protein ligase RNF5 (HsRma1, RING finger protein 5, protein G16, RNF5, G16, NG2, RMA1)
- E3 ubiquitin-protein ligase RNF8; RING finger protein 8 (RNF8, KIAA0646)
- E3 ubiquitin-protein ligase SH3RF2 (SH3 domain-containing RING finger protein 2, RING finger protein 158, SH3RF2 RNF158)
- E3 ubiquitin-protein ligase SHPRH (SNF2, histone-linker, PHD & RING finger domain-containing helicase; SHPRH ;KIAA2023)
- E3 ubiquitin-protein ligase SIAH1; seven in absentia homolog 1; siah-1; siah-1a (SIAH1 HUMSIAH)
- E3 ubiquitin-protein ligase SIAH2; seven in absentia homolog 2; siah-2; hsiah2 (SIAH2)
- E3 ubiquitin-protein ligase synoviolin (synovial apoptosis inhibitor 1, SYVN1, HRD1, KIAA1810)
- E3 ubiquitin-protein ligase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; tumor suppressor p53-binding protein 3; p53-binding protein 3; p53BP3 (TOPORS, LUN, T...
- E3 ubiquitin-protein ligase TRAF7; RING finger & WD repeat-containing protein 1; RING finger protein 119; TNF receptor-associated factor 7 (TRAF7, RFWD1, RNF119)
- E3 ubiquitin-protein ligase TRIM11; tripartite motif-containing protein 11; RING finger protein 92; protein BIA1 (TRIM11, RNF92)
- E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; tumor suppressor RFP2; RING finger protein 77; Ret finger protein 2; tripartite motif-containing protein 13 (TRIM13, LEU5, RFP...
- E3 ubiquitin-protein ligase TRIM17; tripartite motif-containing protein 17; testis RING finger protein; RING finger protein 16 (TRIM17, RBCC, RNF16, TERF)
- E3 ubiquitin-protein ligase TRIM22; EC=6.3.2.-; tripartite motif-containing protein 22; RING finger protein 94; 50 kDa-stimulated trans-acting factor; Staf-50 (TRIM22, RNF94, STAF50)
- E3 ubiquitin-protein ligase TRIM31; tripartite motif-containing protein 31 (TRIM31, C6orf13 RNF)
- E3 ubiquitin-protein ligase TRIM32; tripartite motif-containing protein 32; zinc finger protein HT2A; 72 kD Tat-interacting protein (TRIM32, HT2A)
- E3 ubiquitin-protein ligase TRIM33; tripartite motif-containing protein 33; transcription intermediary factor 1-gamma; TIF1-gamma; ectodermin homolog; RET-fused gene 7 protein; protein Rfg7 (TRIM33, KIAA1113, RFG7, TIF1G)
- E3 ubiquitin-protein ligase TRIM36; tripartite motif-containing protein 36; Zn+2-binding protein Rbcc728; RING finger protein 98 (TRIM36 RBCC728 RNF98)
- E3 ubiquitin-protein ligase TRIM37; tripartite motif-containing protein 37; mulibrey nanism protein (TRIM37, KIAA0898, MUL, POB1)
- E3 ubiquitin-protein ligase TRIM41; tripartite motif-containing protein 41; RING finger-interacting protein with C kinase; RINCK (TRIM41, RINCK)
- E3 ubiquitin-protein ligase TRIM50; tripartite motif-containing protein 50 (TRIM50, TRIM50A)
- E3 ubiquitin-protein ligase TRIP12; thyroid receptor-interacting protein 12; TR-interacting protein 12; TRIP-12 (TRIP12, KIAA0045)
- E3 ubiquitin-protein ligase TTC3; protein DCRR1; RING finger protein 105; TPR repeat protein D; tetratricopeptide repeat protein 3; TPR repeat protein 3 (TTC3, DCRR1, RNF105, TPRD)
- E3 ubiquitin-protein ligase UBR1; N-recognin-1; ubiquitin-protein ligase E3-alpha-1; ubiquitin-protein ligase E3-alpha-I (UBR1)
- E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase, HECT domain-containing 1; hyperplastic discs protein homolog; hHYD; Progestin-induced protein (UBR5, EDD, EDD1, HYD, KIAA0896)
- E3 ubiquitin-protein ligase ZNRF1 (zinc/RING finger protein 1, nerve injury-induced gene 283 protein, ZNRF1, NIN283)
- E3 ubiquitin-protein ligase ZNRF2 (zinc/RING finger protein 2, RING finger protein 202, protein Ells2)
- NEDD4-like E3 ubiquitin-protein ligase WWP1; atrophin-1-interacting protein 5; AIP5; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1 (WWP1)
- NEDD4-like E3 ubiquitin-protein ligase WWP2; atrophin-1-interacting protein 2; AIP2; WW domain-containing protein 2 (WWP2)
- PDZ domain-containing RING finger protein 3; E3 ubiquitin-protein ligase PDZRN3; ligand of Numb protein X 3; semaphorin cytoplasmic domain-associated protein 3; protein SEMACAP3 (PDZRN3, KIAA1095, LNX3, SEMCAP3)
- pellino protein homolog
- probable E3 ubiquitin-protein ligase KIAA0614 (KIAA0614, HECTD4)
- probable E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; protein associated with Myc (MYCBP2, KIAA0916, PAM)
- protein deltex 3-like protein (B-lymphoma- & BAL-associated protein, rhysin-2, DTX3L, BBAP)
- RING finger protein 12; E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; RING finger LIM domain-binding protein; R-LIM; renal carcinoma antigen NY-REN-43 (RLIM, RNF12)
- RING finger protein 13; E3 ubiquitin-protein ligase RNF13 (RNF13 RZF)
- RING finger protein 14; E3 ubiquitin-protein ligase RNF14; androgen receptor-associated protein 54; HFB30; triad2 protein (RNF14, ARA54, HRIHFB2038)
- RING finger protein 19A; E3 ubiquitin-protein ligase RNF19A; double ring-finger protein; dorfin; p38 (RNF19A, RNF19)
- RING finger protein 34; E3 ubiquitin-protein ligase RNF34; caspase regulator CARP1; caspases-8 & -10-associated RING finger protein 1; CARP-1; FYVE-RING finger protein Momo; human RING finger homologous to inhibitor of apoptosis protein; hRFI; RING fin...
- RING finger protein 4; E3 ubiquitin ligase RNF4; small nuclear ring finger protein; protein SNURF (RNF4, SNURF, RES4-26)
- Smad ubiquitination regulatory factor
- UbcH10-binding protein with a HECT-like domain (UBE3D, C6orf157, H10BH)
- ubiquitin ligase protein MIB1; mind bomb homolog 1; DAPK-interacting protein 1; DIP-1; zinc finger ZZ type with ankyrin repeat domain protein 2 (MIB1, DIP1, KIAA1323, ZZANK2)
- ubiquitin ligase protein MIB2; mind bomb homolog 2; zinc finger ZZ type with ankyrin repeat domain protein 1; skeletrophin; novelzin; novel zinc finger protein; NF-kappa-B-activating protein 002N (MIB2, DIP1, KIAA1323, ZZANK2)
- ubiquitin-conjugating enzyme E2 T; cell proliferation-inducing gene 50 protein; ubiquitin carrier protein T; ubiquitin-protein ligase T (UBE2T)
- ubiquitin-conjugating enzyme E2Q2; ubiquitin-protein ligase Q2; ubiquitin carrier protein Q2 (UBE2Q2)
- ubiquitin-conjugating enzyme E2W; ubiquitin-protein ligase W; ubiquitin carrier protein W (UBE2W)
- ubiquitin-like PHD & RING finger domain-containing protein 1; E3 ubiquitin-protein ligase UHRF1; inverted CCAAT box-binding protein of 90 kDa; nuclear protein 95; nuclear zinc finger protein Np95; HuNp95; RING finger protein 106; transcription factor ...
- ubiquitin-like PHD & RING finger domain-containing protein 2; E3 ubiquitin-protein ligase UHRF2; EC=6.3.2.-; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; nuclear protein 97; nuclear zinc finger protein Np97; RING finger protein ...
- ubiquitin-protein ligase E3A; E6AP ubiquitin-protein ligase; human papillomavirus E6-associated protein; oncogenic protein-associated protein E6-AP; renal carcinoma antigen NY-REN-54 (UBE3A, E6AP, EPVE6AP, HPVE6A)
- ubiquitin-protein ligase E3B (UBE3B)
- ubiquitin-protein ligase E3C (UBE3C, UBE3C KIAA0010, KIAA10)
- zinc finger protein 294; E3 ubiquitin-protein ligase listerin; RING finger protein 160 (LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294, HSPC087)
- zinc finger protein 363; RING finger & CHY zinc finger domain-containing protein 1; androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; p53-induced RING-H2 ...
- zinc finger protein 364; E3 ubiquitin-protein ligase RNF115; RING finger protein 115; Rabring 7 (RNF115, ZNF364)
- zinc finger protein 645; E3 ubiquitin-protein ligase ZNF645 (ZNF645)
References
- ↑ Jentsch S et al Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells. TIBS 15(May):195 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2193438
- ↑ Hatakeyama S & Nakayama KI U-box proteins as a new family of ubiquitin ligases. Biochem Biophys Res Comm 302:635-645, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12646216
- ↑ UniProt http://www.uniprot.org/uniprot/Q13191.html