probable E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; protein associated with Myc (MYCBP2, KIAA0916, PAM)

Function

• E3 ubiquitin ligase, ubiquitin conjugation, 3rd step
• mediates ubiquitination & proteasomal degradation
• regulation of transcriptional activation by MYC
• synaptogenesis
• interactions: MYC, TSC2 (tuberin)/TSC1 (hamartin) complex

Structure

• belongs to the highwire family
• contains 1 B box-type Zn+2 finger
• contains 1 DOC domain
• contains 1 filamin repeat
• contains 5 RCC1 repeats
• contains 1 RING-type Zn+2 finger

Compartment

• nucleus
• colocalizes with TSC1 & TSC2 along neurites & growth cones

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues
• especially abundant in brain & thymus

More general terms

• E3 ubiquitin ligase
• nuclear protein
• ring finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23077
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23077
• OMIM: https://mirror.omim.org/entry/610392
• UniProt: http://www.uniprot.org/uniprot/O75592.html