E3 ubiquitin-protein ligase ZNRF2 (zinc/RING finger protein 2, RING finger protein 202, protein Ells2)

Function

• role in establisment & maintenance of neuronal transmission & plasticity via its ubiquitin ligase activity
• ubiquitin conjugation, 3rd step
• interacts with UBE2N
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 1 RING-type zinc finger, required for E3 ligase activity

Compartment

• endosome, lysosome, peripheral membrane protein
• present in presynaptic plasma membranes in neurons

Expression

• highly expressed in the brain, with higher expression during development than in adult
• expressed also in mammary glands, testis, colon, kidney

More general terms

• E3 ubiquitin ligase
• ring finger protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NHG8.html