BRCA1-associated protein (BRAP2, impedes mitogenic signal propagation, IMP, RING finger protein 52, NY-REN-63 antigen, BRAP, RNF52)

Function

• negatively regulates MAP kinase activation by limiting formation of Raf/MEK complexes via inactivation of the KSR1 scaffold protein (putative)
• acts as a Ras responsive E3 ubiquitin ligase
  • on activation of Ras, is modified by auto-polyubiquitination
  • results in release of inhibition of Raf/MEK complex formation
• cytoplasmic retention protein with a role in regulating nuclear transport
• interacts with the nuclear localization signal of BRCA1 & the N-terminal of KSR1
• C-terminal portion of BRCA1 interacts with DDB1

Structure

• contains 1 RING-type zinc finger
• contains 1 UBP-type zinc finger

Compartment

cytoplasm

Expression

expressed in breast epithelial cell line

More general terms

• E3 ubiquitin ligase
• ring finger protein

Database

• OMIM: https://mirror.omim.org/entry/604986
• UniProt: http://www.uniprot.org/uniprot/Q7Z569.html