E3 ubiquitin-protein ligase SIAH2; seven in absentia homolog 2; siah-2; hsiah2 (SIAH2)

Function

• E3 ubiquitin ligase
• mediates ubiquitination & subsequent proteasomal degradation of target proteins.
• triggers the ubiquitin-mediated degradation of
  • proteins involved in transcription regulation
    • POU2AF1, PML, NCOR1
  • cell surface receptor(s)
    • DCC
  • antiapoptotic protein(s)
    • BAG1
  • protein(s) involved in synaptic vesicle function in neurons
    • SYP
• role in:
  • apoptosis
  • tumor suppression
  • cell cycle
  • transcription
  • signaling processes
• has some overlapping function with SIAH1
• triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not

Structure

• the RING-type zinc finger domain is essential for ubiquitin ligase activity

Compartment

cytoplasmic; predominantly, nuclear partially

Expression

widely expressed at low level

More general terms

• zinc finger protein
• E3 ubiquitin ligase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6478
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6478
• OMIM: https://mirror.omim.org/entry/602213
• UniProt: http://www.uniprot.org/uniprot/O43255.html