BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-associated athanogene 1; glucocorticoid receptor-associated protein RAP46 (BAG1, HAP)

Function

• inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release
• inhibits the pro-apoptotic function of PPP1R15A, & has anti-apoptotic activity
• bcl-2 binding protein
• markedly increases the anti-cell death function of BCL2 induced by various stimuli
• ubiquitinated; mediated by SIAH1 or SIAH2 & leading to its subsequent proteasomal degradation (probable)
• binds to the ATPase domain of HSP70/HSC chaperones
• binds to BCL2 & NR3C1
• interacts with N-terminal region of STK19
• interacts with PPP1R15A
• isoform 2 doesn't interact with HSP70/HSC or BCL2

Structure

• contains 1 BAG domain
• contains 1 ubiquitin-like domain

Compartment

• isoform 2: cytoplasm, nucleus; localizes to the cytoplasm & shuttles into the nucleus in response to heat shock

Alternative splicing

named isoforms=2

Pathology

• defects/overactivity in BAG1 may be linked to the cryptophthalmos syndrome (Fraser syndrome)

More general terms

• bcl-2 binding athanogene (bag) protein
• anti apoptotic protein

Database

• OMIM: https://mirror.omim.org/entry/601497
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=573
• UniProt: http://www.uniprot.org/uniprot/Q99933.html