heat shock cognate 71 kD protein (heat shock 70 kD protein 8, HSPA8, HSC70, HSP73, HSPA10)
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Function
- chaperone
- isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the cochaperones
- interacts with HSPH1/HSP105 (putative)
- interacts with PACRG & TSC2
- phosphorylated upon DNA damage, probably by ATM or ATR
- uncoating enzyme, drives disassembly of clathrin coat[1][2]?
Structure
belongs to the heat shock protein 70 family
Compartment
- cytoplasm, melanosome
- translocates rapidly from cytoplasm to nuclei, & especially to the nucleoli, upon heat shock
Alternative splicing
named isoforms=2
Expression
- ubiquitous
- constitutively synthesized
More general terms
References
- ↑ 1.0 1.1 Arlan Richardson, AGE meeting Oct 3-6, 1990 New York, NY
- ↑ 2.0 2.1 Martinus RD et al Role of chaperones in the biogenesis and maintenance of the mitochondrion. FASEB J. 1995 Mar;9(5):371-8. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7896006
- ↑ UniProt http://www.uniprot.org/uniprot/P11142.html