heat shock protein 105 kD; heat shock 110 kD protein; antigen NY-CO-25 (HSPH1, HSP105, HSP110, KIAA0201)

Function

• prevents aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly
• inhibits HSPA8/HSC70 ATPase & chaperone activities
• phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity (putative)
• interacts with HSPA8/HSC70 (putative)

Structure

belongs to the heat shock protein 70 family

Compartment

cytoplasm

Alternative splicing

named isoforms=3; alpha, beta

Expression

• highly expressed in testis
• low expression in most brain regions
• not expressed in cerebellum

Pathology

• overexpressed in cancer cells

More general terms

• heat shock protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10808
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10808
• OMIM: https://mirror.omim.org/entry/610703
• UniProt: http://www.uniprot.org/uniprot/Q92598.html