parkin coregulated gene protein; molecular chaperone/chaperonin-binding protein; PARK2 coregulated gene protein (PACRG, GLUP)

Function

• suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of parkin)
• facilitates formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules & itself when proteasome is inhibited
• may play a role in formation of Lewy bodies & protection of dopaminergic neurons against parkinson disease
• forms a large molecular chaperone complex containing heat shock proteins 70 & 90 & chaperonin components
• interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8

Alternative splicing

• named isoforms=2
• may be due to exon skipping

Expression

• expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte & bone marrow
• also expressed in heart, brain, skeletal muscle, kidney, lung & pancreas
• expressed in primary Schwann cells & very weakly by monocyte- derived macrophages the primary host cells of Mycobacterium lepra

Pathology

• component of Lewy bodies, intraneuronal inclusions found in brain of patients with Parkinson disease

Genetics

• linked to PARK2 in a head-to-head arrangement on opposite DNA strands & share a common 5'-flanking promoter region

Polymorphism

• involved in susceptibility to leprosy
• associated with polymorphisms in the 5'-regulatory region shared by the PARK2 gene

More general terms

• other protein

Additional terms

• leprosy (Hansen's disease)
• parkin gene

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=135138
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:135138
• OMIM: https://mirror.omim.org/entry/607572
• OMIM: https://mirror.omim.org/entry/608427
• UniProt: http://www.uniprot.org/uniprot/Q96M98.html