E3 ubiquitin-protein ligase parkin; EC=6.3.2.-; parkinson juvenile disease protein 2; parkinson disease protein 2 (PARK2 PRKN)

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Function

Structure

Compartment

Alternative splicing

named isoforms=5

Expression

Pathology

Notes

  • the parkin locus (PRKN), adjacent to the 6q telomere is hyper-recombinable & lies within FRA6E, the 3rd most common fragile site in tumor tissue

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/O60260.html
  2. GeneReviews http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/PARK2
  3. 3.0 3.1 Kitada T et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-8, 1998 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9560156
  4. Journal Watch 22(1):8, 2002 Shimura H et al Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293:263, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11431533
  5. Chung KK et al. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science 304:1328-31, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/15105460
  6. 6.0 6.1 Rana A, Rera M, Walker DW. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A. 2013 May 6 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23650379

Database