cullin homolog 1 (CUL-1)

Function

• core component of SCF complex(es)
  • component of the SCF(FBXW11) complex containing FBXW11
  • component of the SCF(SKP2) complex containing SKP2, in which it interacts directly with SKP1, SKP2 & RBX1
  • component of the SCF(FBXW2) complex containing FBXw2
  • component of the SCF(FBXO32) complex containing FBXO32
  • component of the probable SCF(FBXO7) complex containing FBXO7
  • component of the SCF(FBXO11) complex containing FBXO11
  • component of the SCF(FBXO25) complex containing FBXO25
  • component of the SCF(FBXO33) complex containing FBXO33
  • component of the probable SCF(FBXO4) complex containing FBXO4
  • component of the SCF(BTRC) complex, composed of SKP1, CUL1 & BTRC; this complex binds phosphorylated NFKBIA
• in the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein & RBX1 subunits
• may contribute to catalysis through positioning of the substrate & the ubiquitin-conjugating enzyme
• the E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit & is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1
• neddylation enhances ubiquitination activity of SCF
• deneddylated via its interaction with the CSN complex (COP9 signalosome complex)
• interacts with RNF7
• selectively interacts with SKP1 & forms complex with SKP2 & cyclin A
• part of a complex with TIP120A/CAND1 & RBX1
• the unneddylated form interacts with TIP120A/CAND1 & the interaction negatively regulates the association with SKP1 in the SCF complex
• interacts with COPS2. can self-associate
• interacts with FBXW8.
• interacts with CUL7; the interaction seems to be mediated by FBXW8

Structure

belongs to the cullin family

Expression

expressed in lung fibroblasts

More general terms

• cullin
• scaffold protein

Component of

• SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8454
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8454
• OMIM: https://mirror.omim.org/entry/603134
• UniProt: http://www.uniprot.org/uniprot/Q13616.html