S-phase kinase-associated protein 2; F-box protein Skp2; cyclin-A/CDK2-associated protein p45; p45skp2; F-box/LRR-repeat protein 1 (SKP2 FBXL1)

Function

• substrate recognition component of a SCF complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction & transcription
• specifically recognizes phosphorylated CDKN1B/p27kip
• role in regulation of G1/S transition
• degradation of CDKN1B/p27kip also requires CKS1 recognizes target proteins ORC1L, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, & probably MYC, TOB1 & TAL1
• degradation of TAL1 also requires STUB1
• recognizes CDKN1A in association with CCNE1 or CCNE2 & CDK2
• interacts directly with CUL1 & SKP1
• interacts with CKS1
• interacts with the cyclin-A-CDK2 complex
• interacts with ORC1L, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1A, UBP43, MYC, TOB1, TAL1 & MLL

Structure

• contains 1 F-box domain
• contains 8 LRR repeats (leucine-rich repeats)

Alternative splicing

named isoforms=2

More general terms

• Skp (S phase kinase associated protein) family protein
• leucine-rich repeat-containing protein (LRRC)
• phosphoprotein

Component of

• SKP1-CUL1-F-box protein (SCF) complex; SCF(FBXW11) E3 ligase complex; CF(SKP2) E3 ligase complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6502
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6502
• OMIM: https://mirror.omim.org/entry/601436
• UniProt: http://www.uniprot.org/uniprot/Q13309.html