DNA replication factor Cdt1; double parked homolog; DUP (CDT1)

Function

• cooperates with CDC6 to promote loading of mini-chromosome maintenance complex onto chromatin to form pre-replication complex necessary to initiate DNA replication
• binds DNA (sequence-, strand-, & conformation-independent)
• potential oncogene protein
• interaction with geminin (GMNN) inhibits both binding of MCM complex to origins of replication & DNA-binding activity which may prevent inappropriate replication origin firing
• ubiquitinated, leading to its subsequent degradation
• interaction with GMNN protects it against ubiquitination
• phosphorylation by cyclin A-dependent kinases resulting in binding of CDT1 to F-box protein SKP2 & subsequent degradation
• binding to GMNN is not affected by phosphorylation

Structure

• belongs to the Cdt1 family

Compartment

• nucleus

Expression

• present during G1 phase & early S phase of cell cycle
• degraded during the late S phase, G2 phase, & M phase

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81620
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81620
• OMIM: https://mirror.omim.org/entry/605525
• UniProt: http://www.uniprot.org/uniprot/Q9H211.html