cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6 (CDC6, CDC18L)

Function

• role in the initiation of DNA replication
• also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated
• interacts with PCNA, ORC1L, cyclin-CDK & HUWE1

Structure

belongs to the CDC6/cdc18 family

Compartment

• nucleus. cytoplasm
• nuclear in G1 & cytoplasmic in S-phase cells

Pathology

• defects in CDC6 are the cause of Meier-Gorlin syndrome type 5

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=990
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:990
• OMIM: https://mirror.omim.org/entry/602627
• OMIM: https://mirror.omim.org/entry/613805
• UniProt: http://www.uniprot.org/uniprot/Q99741.html