origin recognition complex subunit 1 (ORC1L, replication control protein 1, ORC1, PARC1)

Function

• component of the origin recognition complex (ORC) that binds origins of replication
• role in both chromosomal replication & mating type transcriptional silencing
• binds to the ARS consensus sequence of origins of replication (ATP-dependent)
• interacts with CDC6 & MYST2/HBO1

Structure

• belongs to the ORC1 family
• contains 1 BAH domain

Compartment

nucleus

More general terms

• protein subunit
• nuclear protein
• phosphoprotein

Component of

• origin of replication complex (origin recognition complex, ORC)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4998
• OMIM: https://mirror.omim.org/entry/601902
• UniProt: http://www.uniprot.org/uniprot/Q13415.html