histone acetyltransferase KAT7; histone acetyltransferase binding to ORC1; lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 2; MYST-2 (KAT7, HBO1, HBOa, MYST2)

Function

• histone acetyltransferase
• specifically represses AR-mediated transcription
• DNA replication (putative)
• interacts with MCM2, ORC1L, androgen receptor in presence of dihydrotestosterone
• component of the HBO1 complex
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• the C2HC-type Zn+2 finger is required for interaction with MCM2 & ORC1L
• the N-terminus is involved in transcriptional repression,
• the C-terminus mediates AR-interaction (putative)
• belongs to the MYST (SAS/MOZ) family
• contains 1 C2HC-type Zn+2 finger

Compartment

nucleus

Expression

• ubiquitously expressed
• highest levels in testis

More general terms

• histone acetyltransferase
• nuclear protein
• zinc finger protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11143
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11143
• OMIM: https://mirror.omim.org/entry/609880
• UniProt: http://www.uniprot.org/uniprot/O95251.html