histone acetyltransferase MYST3; MYST protein 3; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 3; Runt-related transcription factor-binding protein 2; monocytic leukemia zinc finger protein; zinc finger protein 220 (MYST3, MOZ, RUNXBP2, ZNF220, KAT6A)
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Function
- histone acetyltransferase
- may act as a transcriptional coactivator for RUNX1 & RUNX2
- interacts with RUNX1 & RUNX2
- autoacetylated
- phosphorylated upon DNA damage, probably by ATM or ATR
acetyl-CoA + histone <--> CoA + acetylhistone
Structure
- N-terminus is involved in transcriptional activation
- C-terminus is involved in transcriptional repression
- belongs to the MYST (SAS/MOZ) family
- contains 1 C2HC-type Zn+2 finger
- contains 2 PHD-type Zn+2 fingers
Compartment
- nucleus
- partially concentrated in subnuclear foci distinct from PML bodies, & excluded from the nucleoli
Pathology
- chromosomal aberrations involving MYST3 may be a cause of acute myeloid leukemias
- translocation t(8;16)(p11;p13) with CREBBP; fusion protein MYST3-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription
- translocation t(8;22)(p11;q13) with EP300
- inversion inv(8)(p11;q13) generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3 & the C-terminus part of NCOA2; MYST3-NCOA2 binds to CREBBP & disrupts its function in transcription activation
- chromosomal translocation t(2;8)(p23;p11.2) involving MYST3 with ASXL2 is a cause of therapy-related myelodysplastic syndrome; translocation generates a MYST3-ASXL2 fusion protein
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q92794.html
- ↑ Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/MYST3ID25ch8p11.html
- ↑ Marks P, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer. 2001 Dec;1(3):194-202. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11902574