chromosomal inversion inv(8)(p11;q13)

Introduction

• chromosomal inversion inv(8)(p11;q13) involving NCOA2 may be a cause of acute myeloid leukemias
  • the inversion generates the MYST3-NCOA2 oncogene, which consists of the N-terminus part of MYST3/MOZ & the C-terminus part of NCOA2/TIF2
  • MYST3-NCOA2 binds to CREBBP & disrupts its function in transcription activation

More general terms

• chromosomal inversion