core-binding factor [CBF]-alpha 2; runt-related transcription factor 1; acute myeloid leukemia 1 protein; polyomavirus enhancer binding protein 2 alpha B subunit; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit;SL3/AKV core-binding factor alpha B subunit (RUNX1, AML1, CBFA2)

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Function

Structure

Compartment

nucleus

Alternative splicing

Expression

Pathology

Laboratory

More general terms

References

  1. Meyers et al, Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein- protein interactions. Mol Cell Biol 13(10):6336 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8413232
  2. 2.0 2.1 Okuda et al. AML1, the target of multiple chromosomal translocations in in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84:321-30 1996 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8565077
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/AML1.html
  4. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=RUNX1
  5. UniProt http://www.uniprot.org/uniprot/Q01196.html

Database