transducin-like enhancer protein 1; E(Sp1) homolog; enhancer of split groucho-like protein 1; ESG1 (TLE1)

Function

• transcriptional corepressor that binds to a number of transcription factors
• inhibits NF-kappa-B-regulated gene expression
• inhibits the transcriptional activation mediated by FOXA2, & by CTNNB1 & TCF family members in Wnt signaling
• the effects of full-length TLE family members may be modulated by association with dominant-negative AES
• unusual function as coactivator for ESRRG
• phosphorylated, probably by CDK1
• degree of phosphorylation varies throughout the cell cycle,
  • highest at the G2/M transition
• hyperphosphorylated in response to cell differentiation & interaction with HES1 or RUNX1
• homooligomer & heterooligomer with other family members
• binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG & the NF-kappa-B subunit RELA
• interacts with HES1 (via WRPW motif)

Structure

• belongs to the WD repeat groucho/TLE family
• contains 6 WD repeats

Compartment

• nucleus
• nuclear & chromatin-associated, depending on isoforms & phosphorylation status
• hyperphosphorylation decreases the affinity for nuclear components

Expression

• in all tissues examined, mostly in brain, liver & muscle

More general terms

• transducin-like enhancer protein (ESG)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7088
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7088
• OMIM: https://mirror.omim.org/entry/600189
• UniProt: http://www.uniprot.org/uniprot/Q04724.html