amino-terminal enhancer of split; amino enhancer of split; GRG protein; protein ESP1; Gp130-associated protein GAM (AES, GRG)

Function

• acts as dominant repressor towards other family members
• inhibits NF-kappa-B-regulated gene expression
• may be required for initiation & maintenance of cellular differentiation
• homooligomer & heterooligomer with other family members
• binds TCF7 (putative)
• binds the NF-kappa-B subunit RELA
• interacts with PHF12

Structure

• lacks the C-terminal WD repeats
• belongs to the WD repeat groucho/TLE family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• found predominantly in muscle, heart & placenta
• in fetal tissues, abundantly expressed in the heart, lung, kidney, brain & liver

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08117.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=166
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:166
• OMIM: https://mirror.omim.org/entry/600188