PHD finger protein 12; PHD factor 1; Pf1 (PHF12, KIAA1523)

Function

• transcriptional repressor
• role in recruitment of functional SIN3A complexes to DNA.
• represses transcription at least in part through the activity of an associated histone deacetylase
• may also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA
• isoform 2 interacts with SIN3A in a complex composed of HDAC1, SAP30 & SIN3A
• interacts with AES

Structure

• contains 1 FHA domain
• contains 2 PHD-type zinc fingers

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• zinc finger protein
• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96QT6.html