paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A)

Function

• transcriptional repressor
• interacts with MXI1 to repress MYC responsive genes
• antagonizes MYC oncogenic activities
• interacts with MAD-MAX heterodimers by binding to MAD; heterodimer then represses transcription by tethering SIN3A to DNA
• component of Sin3A corepressor complex
• interacts with MBD2, SAP30, NCOR1, SDS3, MXI1, MAD, DACH1, HCFC1, SFPQ
• component of complex consisting of HDAC1, PHF12 & SAP30

Structure

• PAH domain 2 of mSin3A/mSin3B required for MAD & Mxi binding; first 25 aa of MAD also required.

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Additional terms

• sin3-protein

Component of

• Sin3A corepressor complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25942
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25942
• OMIM: https://mirror.omim.org/entry/607776
• UniProt: http://www.uniprot.org/uniprot/Q96ST3.html