Dachshund homolog 1 (Dach1)

Function

• regulation of organogenesis
• regulation of SIX1, SIX6, probably SIX5
• direct repression of cyclin dependent kinase inhibitors
• inhibits TGF-beta signaling through interaction with MADH4 & NCOR1
• interact with SIX1, SIX6, EYA3, NCOR1, HDAC3, SIN3A, MADH3, MADH4

Alternative splicing

4 splice forms

Expression

• widely expressed
• isoform 2: brain, heart, kidney, liver, leukocytes, spleen
• isoform 3: liver, heart
• isoform 4: spleen

Genetics

gene locus: 13q22

More general terms

• transcription factor (TF)

Additional terms

• Dachshund homolog 2 (Dach2)
• TGF-beta signalling

Database

• OMIM: https://mirror.omim.org/entry/603803
• UniProt: http://www.uniprot.org/uniprot/Q9UI36.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1602