homeobox protein SIX6; homeodomain protein OPTX2; optic homeobox 2; sine oculis homeobox homolog 6 (SIX6, OPTX2, SIX9)

Function

• may be involved in eye development

Structure

• belongs to the SIX/sine oculis homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus (putative)

Expression

• expressed in the developing & adult retina
• also expressed in the hypothalamic & the pituitary regions

Pathology

• defects in SIX6 are the cause of microphthalmia isolated with cataract type 2

More general terms

• homeobox protein SIX; sine oculis homeobox homolog (SIX)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4990
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4990
• OMIM: https://mirror.omim.org/entry/212550
• OMIM: https://mirror.omim.org/entry/606326
• UniProt: http://www.uniprot.org/uniprot/O95475.html