histone deacetylase 3 (HDAC3, HD3, RPD3-2, SMAP45)

Function

• see histone deacetylase
• deacetylation of Lys on N-terminal part of core histones (H2A, H2B, H3 & H4)
• probably participates in regulation of transcription through its binding to the Zn+2-finger transcription factor YY1
• increases YY1 repression activity
• required to repress transcription of POU1F1
• interacts with HDAC7 & HDAC9
• forms a heterologous complex at least with YY1
• interacts with DAXX, HDAC10 & DACH1
• found in a complex with NCOR1 & NCOR2
• component of the N-Cor repressor complex
• interacts with BCOR, MJD2A/JHDM3A, NRIP1 & SRY
• interacts with BTBD14B
• interacts with GLIS2
• interacts with CBFA2T3
• sumoylated in vitro

Structure

• belongs to the histone deacetylase family, type 1 subfamily

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

widely expressed

More general terms

• histone deacetylase

Component of

• N-cor repressor complex

Database

• UniProt: http://www.uniprot.org/uniprot/O15379.html
• OMIM: https://mirror.omim.org/entry/605166
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8841