histone H4 (HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4)

Function

• core component of nucleosome
• acetylation at Lys-6, Lys-9, Lys-13 & Lys-17 occurs in coding regions of the genome but not in heterochromatin
• citrullination at Arg-4 by PADI4 impairs methylation
• monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 & Lys-13
• demethylation by JMJD6
• monomethylated, dimethylated or trimethylated at Lys-21
• monomethylation by SET8
• trimethylation by SUV420H1 & SUV420H2 induces gene silencing
• ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation; this may weaken the interaction between histones & DNA & facilitate DNA accessibility to DNA repair proteins
• sumoylation is associated with transcriptional repression

Structure

belongs to the histone H4 family

Compartment

nucleus

More general terms

• histone
• phosphoprotein

Component of

• nucleosome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=121504
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=554313
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8294
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8359
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8360
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8361
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8362
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8363
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8364
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8365
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8366
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8367
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8368
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8370
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:121504
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:554313
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8294
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8359
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8360
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8361
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8362
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8363
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8364
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8365
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8366
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8367
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8368
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8370
• OMIM: https://mirror.omim.org/entry/142750
• OMIM: https://mirror.omim.org/entry/602822
• OMIM: https://mirror.omim.org/entry/602823
• OMIM: https://mirror.omim.org/entry/602824
• OMIM: https://mirror.omim.org/entry/602825
• OMIM: https://mirror.omim.org/entry/602826
• OMIM: https://mirror.omim.org/entry/602827
• OMIM: https://mirror.omim.org/entry/602828
• OMIM: https://mirror.omim.org/entry/602829
• OMIM: https://mirror.omim.org/entry/602830
• OMIM: https://mirror.omim.org/entry/602831
• OMIM: https://mirror.omim.org/entry/602833
• UniProt: http://www.uniprot.org/uniprot/P62805.html