protein sumoylation
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Introduction
Conjugation of a target protein with a SUMO protein (small ubiquitin-related modifier). The SUMO protein modifies an epsilon amino group of lysine in the target protein thus changing conformation of the conjugated protein. Sumoylation is reversible via SUMO-specific ligases & SUMO-specific proteases.
Protein sumoylation has been implicated in:[3]
- cell cycle progression
- nuclear import
- regulation of transcription
- protein turnover (including the amyloid precursor protein)
- sumoylation competes with ubiquitination
More general terms
Additional terms
References
- ↑ Gene Ontology Browser (Mouse) GO:0016925 http://www.informatics.jax.org/searches/GO_form.shtml
- ↑ http://www.biocarta.com/pathfiles/h_sumoPathway.asp
- ↑ 3.0 3.1 Hemelaar J, Borodovsky A, Kessler BM, Reverter D et al Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol. 2004 Jan;24(1):84-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/14673145
- ↑ Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12506199