amyloid precursor protein; A4/beta amyloid precursor protein (APP)

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Introduction

Terminology of peptide cleavage fragments:

Function

Structure

  • APP-751 & APP-770 contain a Kunitz protease inhibitor domain

Compartment

Alternative splicing

Expression

Pathology

Laboratory

Comparative biology

  • highly conserved in evolution
  • expressed in all mammals
  • an APP homolog is found in Drosophila

More general terms

Additional terms

References

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  2. Kang J et al The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733 1987 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2881207
  3. Ponte P et al A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331:525 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2893289
  4. Tanzi RE et al Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331:528 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2893290
  5. Kitaguchi N et al Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 331:530 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2893291
  6. Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 1992 Jun 11;357(6378):500-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1608449
  7. Nishimoto I, Okamoto T, Matsuura Y, Takahashi S, Okamoto T, Murayama Y, Ogata E. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o) Nature. 1993 Mar 4;362(6415):75-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8446172
  8. Miyazaki K, Hasegawa M, Funahashi K, Umeda M. A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature. 1993 Apr 29;362(6423):839-41. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8479521
  9. 9.0 9.1 Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell. 1999 Apr 30;97(3):395-406. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10319819
  10. 10.0 10.1 Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS. Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature. 2001 Dec 6;414(6864):643-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11740561
  11. 11.0 11.1 Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343
  12. Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=351
  13. 13.0 13.1 Li Y, Wang H, Wang S, Quon D, Liu YW, Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. Epub 2002 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9102. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12506199
  14. 14.0 14.1 14.2 Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nat Med. 2000 Apr;6(4):397-404. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10742146
  15. Pietrzik CU et al, FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci. 2004 Apr 28;24(17):4259-65. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15115822
  16. 16.0 16.1 16.2 Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M. Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol Cell Biol. 2005 Nov;25(21):9304-17. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16227582
  17. Shubert D, Schroeder R, LaCorbiere M, Saitoh T, Cole G. Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein. Science 241:223 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2968652

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