APP gene

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Introduction

Motifs from cloned rat promoter region (ref 2). Nucleotide & amino acid numbering with APP-770 as reference. The gene appears to be a constitutively expressed "housekeeping gene", but modulated by conditions of oxidative stress as well (i.e. regulation by redox-modulated transcription factors AP1, Sp1 & NF-kappa B). Clusters of mutations in the APP-gene give give to familial Alzheimer's disease type 1.

↑ Lahiri DK, Robakis NK. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences. Brain Res Mol Brain Res. 1991 Feb;9(3):253-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1851527
↑ Salbaum et al EMBO J 7:2807 1988
↑ Kang J, Muller-Hill B. Differential splicing of Alzheimer's disease amyloid A4 precursor RNA in rat tissues: PreA4(695) mRNA is predominantly produced in rat and human brain. Biochem Biophys Res Commun. 1990 Feb 14;166(3):1192-200. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1689572
↑ Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y. Genomic organization of the human amyloid beta-protein precursor gene. Gene. 1990 Mar 15;87(2):257-63. Erratum in: Gene. 1991 Jun 30;102(2):291-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2110105
↑ Quitschke WW, Goldgaber D. The amyloid beta-protein precursor promoter. A region essential for transcriptional activity contains a nuclear factor binding domain. J Biol Chem. 1992 Aug 25;267(24):17362-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1380960
↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343